Alaa A.M. Abdel-Aziz : rechercher sur Z-Library

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1

Design, synthesis and biological evaluation of novel quinazoline derivatives as potential antitumor agents: Molecular docking study

Adel S. El-Azab, Mohamed A. Al-Omar, Alaa A.-M. Abdel-Aziz, Naglaa I. Abdel-Aziz, Magda A.-A. El-Sayed, Abdulaziz M. Aleisa, Mohamed M. Sayed-Ahmed, Sami G. Abdel-Hamide

Journal:

European Journal of Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 990 KB

english, 2010

2

Synthesis, Ultra-Short Acting Hypnotic Activity, and Metabolic Profile of Ethyl 8-Oxo-5,6,7,8-tetrahydro-thiazolo[3,2-a] [1,3]diazepin-3-carboxylate (HIE-124)

Adnan A. Kadi, Hassan A. El-Kashef, Alaa A.-M. Abdel-Aziz, Ghada S. Hassan, Justice Tettey, Mary H. Grant, Jochen Lehmann, Hussein I. El-Subbagh

Journal:

Archiv der Pharmazie

Année:

2008

Langue:

english

Fichier:

PDF, 726 KB

english, 2008

3

Design, synthesis and antibacterial activity of fluoroquinolones containing bulky arenesulfonyl fragment: 2D-QSAR and docking study

Alaa A.-M. Abdel-Aziz, Yousif A. Asiri, Mohamed H.M. Al-Agamy

Journal:

European Journal of Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 822 KB

english, 2011

4

[Profiles of Drug Substances, Excipients and Related Methodology] Volume 37 || Flurbiprofen

Abdel-Aziz, Alaa A.-M.

Année:

2012

Langue:

english

Fichier:

PDF, 24 KB

english, 2012

5

[Profiles of Drug Substances, Excipients and Related Methodology] Volume 36 || Tadalafil

Abdel-Aziz, Alaa A.-M.

Année:

2011

Langue:

english

Fichier:

PDF, 4.22 MB

english, 2011

6

Synthesis, antitumor activity and molecular docking study of some novel 3-benzyl-4(3H)quinazolinone analogues

Al-Suwaidan, Ibrahim A., Abdel-Aziz, Alaa A.-M., Shawer, Taghreed Z., Ayyad, Rezk R., Alanazi, Amer M., El-Morsy, Ahmad M., Mohamed, Menshawy A., Abdel-Aziz, Naglaa I., El-Sayed, Magda A.-A., El-Azab,

Journal:

Journal of Enzyme Inhibition and Medicinal Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 849 KB

english, 2015

7

Synthesis, anticancer and apoptosis-inducing activities of quinazoline–isatin conjugates: epidermal growth factor receptor-tyrosine kinase assay and molecular docking studies

El-Azab, Adel S., Al-Dhfyan, Abdullah, Abdel-Aziz, Alaa A.-M., Abou-Zeid, Laila A., Alkahtani, Hamad M., Al-Obaid, Abdulrahman M., Al-Gendy, Manal A.

Journal:

Journal of Enzyme Inhibition and Medicinal Chemistry

Année:

2017

Langue:

english

Fichier:

PDF, 1.62 MB

english, 2017

8

Synthesis and biological evaluation of 2-styrylquinolines as antitumour agents and EGFR kinase inhibitors: molecular docking study

El-Sayed, Magda A.-A., El-Husseiny, Walaa M., Abdel-Aziz, Naglaa I., El-Azab, Adel S., Abuelizz, Hatem A., Abdel-Aziz, Alaa A.-M.

Journal:

Journal of Enzyme Inhibition and Medicinal Chemistry

Année:

2018

Langue:

english

Fichier:

PDF, 2.61 MB

english, 2018

9

Synthesis and biological evaluation of novel xanthine derivatives as potential apoptotic antitumor agents

Hisham, Mohamed, Youssif, Bahaa G.M., Osman, Essam Eldin A., Hayallah, Alaa M., Abdel-Aziz, Mohamed

Journal:

European Journal of Medicinal Chemistry

Année:

2019

Langue:

english

Fichier:

PDF, 1.51 MB

english, 2019

10

Synthesis, antitumor activity, and molecular docking study of 2-cyclopentyloxyanisole derivatives: mechanistic study of enzyme inhibition

El-Husseiny, Walaa M., El-Sayed, Magda A.-A., El-Azab, Adel S., AlSaif, Nawaf A., Alanazi, Mohammed M., Abdel-Aziz, Alaa A.-M.

Journal:

Journal of Enzyme Inhibition and Medicinal Chemistry

Année:

2020

Langue:

english

Fichier:

PDF, 2.35 MB

english, 2020

11

S-substituted 2-mercaptoquinazolin-4(3H)-one and 4-ethylbenzensulfonamides act as potent and selective human carbonic anhydrase IX and XII inhibitors

El-Azab, Adel S., Abdel-Aziz, Alaa A.-M., Bua, Silvia, Nocentini, Alessio, AlSaif, Nawaf A., Alanazi, Mohammed M., El-Gendy, Manal A., Ahmed, Hany E. A., Supuran, Claudiu T.

Journal:

Journal of Enzyme Inhibition and Medicinal Chemistry

Année:

2020

Langue:

english

Fichier:

PDF, 2.65 MB

english, 2020

12

ChemInform Abstract: An Unusual Enhancement of Chiral Induction by Chiral 2-Imidazolidinone Auxiliaries.

Alaa A.-M. Abdel-Aziz, Junko Okuno, Shinsuke Tanaka, Tadao Ishizuka, Hirofumi Matsunaga, Takehisa Kunieda

Journal:

Année:

2001

Fichier:

PDF, 28 KB

2001

13

ChemInform Abstract: Versatile Chiral Synthons for 1,2-Diamines: (4S,5S)- and (4R,5R)-4,5-Dimethoxy-2-imidazolidinones.

Ryushi Seo, Tadao Ishizuka, Alaa A.-M. Abdel-Aziz, Takehisa Kunieda

Journal:

Année:

2001

Fichier:

PDF, 30 KB

2001

14

ChemInform Abstract: Unusual N-Acylation of Sterically Congested trans-4,5-Disubstituted 2-Imidazolidinones: Remarkably Facile C—C Bond Formation.

Alaa A.-M. Abdel-Aziz, Hirofumi Matsunaga, Takehisa Kunieda

Journal:

Année:

2002

Fichier:

PDF, 32 KB

2002

15

ChemInform Abstract: Substituted Quinazolines. Part 3. Synthesis, in vitro Antitumor Activity and Molecular Modeling Study of Certain 2-Thieno-4(3H)-quinazolinone Analogues.

Abdulrahman M. Al-Obaid, Sami G. Abdel-Hamide, Hassan A. El-Kashef, Alaa A.-M. Abdel-Aziz, Adel S. El-Azab, Hamad A. Al-Khamees, Hussein I. El-Subbagh

Journal:

Année:

2009

Fichier:

PDF, 40 KB

2009

16

ChemInform Abstract: Synthesis of Novel Pyrazole Derivatives and Evaluation of Their Antidepressant and Anticonvulsant Activities.

Mohamed Abdel-Aziz, Gamal El-Din A. Abuo-Rahma, Alaa A. Hassan

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 25 KB

english, 2009

17

ChemInform Abstract: Synthesis of [1,2,4]Triazolo[3,4-b][1,3]thiazine-5-carboxylates via One-Pot Reaction of N-Substituted-hydrazino-carbothioamides with Diethyl Maleate.

Ashraf A. Aly, Alaa A. Hassan, Yusria R. Ibrahim, Mohamed Abdel-Aziz

Journal:

Année:

2009

Fichier:

PDF, 25 KB

2009

18

ChemInform Abstract: Synthesis and Antitumor Evaluation of Novel Cyclic Arylsulfonylureas: ADME-T and Pharmacophore Prediction.

Ibrahim M. El-Deeb, Said M. Bayoumi, Magda A. El-Sherbeny, Alaa A.-M. Abdel-Aziz

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 26 KB

english, 2010

19

ChemInform Abstract: Synthesis, Antiinflammatory Activity and COX-1/COX-2 Inhibition of Novel Substituted Cyclic Imides. Part 1. Molecular Docking Study.

Alaa A.-M. Abdel-Aziz, Kamal E. H. ElTahir, Yousif A. Asiri

Journal:

Année:

2011

Fichier:

PDF, 28 KB

2011

20

ChemInform Abstract: Synthesis of Novel Spiro(indolone-3,2′-[1,3,4]thiadiazol)-2-ones and Evaluation of Their Antidepressant and Anticonvulsant Activities.

Alaa A. Hassan, Fathy F. Abdel-Latif, Ahmed M. Nour El-Din, Mohamed Abdel-Aziz, Sara M. Mostafa, Stefan Braese

Journal:

Année:

2012

Fichier:

PDF, 23 KB

2012

21

ChemInform Abstract: Synthesis and Anticonvulsant Activity of Some New Thiazolo[3,2-a][1,3]diazepine, Benzo[d]thiazolo[5,2-a][12,6]diazepine and Benzo[d]oxazolo[5,2-a][12,6]diazepine Analogues.

Hussein I. El-Subbagh, Ghada S. Hassan, Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Adnan A. Kadi, Abdulrahman M. Al-Obaid, Othman A. Al-Shabanah, Mohamed M. Sayed-Ahmed

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 29 KB

english, 2012

22

New polycrystalline solid state responsive electrodes for the determination of the selenite ion

Mohsen M. Zareh, Alaa S. Amin, Manar Abdel-Aziz

Journal:

Electroanalysis

Année:

1995

Langue:

english

Fichier:

PDF, 378 KB

english, 1995

23

Synthesis of [1,2,4]triazolo[3,4-b][1,3]thiazine-5-carboxylates via one-pot reaction of N-substituted-hydrazino-carbothioamides with diethyl maleate

Ashraf A. Aly, Alaa A. Hassan, Yusria R. Ibrahim, Mohamed Abdel-Aziz

Journal:

Journal of Heterocyclic Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 220 KB

english, 2009

24

Synthesis of novel spiro(indolone-3,2′-[1,3,4]thiadiazol)-2-ones and evaluation of their antidepressant and anticonvulsant activities

Alaa A. Hassan, Fathy F. Abdel-Latif, Ahmed M. Nour El-Din, Mohamed Abdel-Aziz, Sara M. Mostafa, Stefan Bräse

Journal:

Journal of Heterocyclic Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 138 KB

english, 2011

25

Potentiometric membrane sensors for the selective determination of cinnarizine in pharmaceutical preparations

Saad S.M. Hassan, Ragab M. Abdel-Aziz, Alaa B. Abbas

Journal:

Analytica Chimica Acta

Année:

1996

Langue:

english

Fichier:

PDF, 338 KB

english, 1996

26

Synthesis, antimicrobial activity and conformational analysis of novel substituted pyridines: BF3-promoted reaction of hydrazine with 2-alkoxy pyridines

Fatma E. Goda, Alaa A.-M. Abdel-Aziz, Omer A. Attef

Journal:

Bioorganic & Medicinal Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 352 KB

english, 2004

27

Synthesis and biological evaluation of novel 6-nitro-5-substituted aminoquinolines as local anesthetic and anti-arrhythmic agents: molecular modeling study

Fatma E. Goda, Alaa A.-M. Abdel-Aziz, Hamdy A. Ghoneim

Journal:

Bioorganic & Medicinal Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 306 KB

english, 2005

28

Lewis acid-promoted transformation of 2-alkoxypyridines into 2-aminopyridines and their antibacterial activity. Part 2: Remarkably facile C–N bond formation

Alaa A.-M. Abdel-Aziz, Hussein I. El-Subbagh, Takehisa Kunieda

Journal:

Bioorganic & Medicinal Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 472 KB

english, 2005

29

Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study

Magda A.-A. El-Sayed, Naglaa I. Abdel-Aziz, Alaa A.-M. Abdel-Aziz, Adel S. El-Azab, Yousif A. Asiri, Kamal E.H. ElTahir

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 704 KB

english, 2011

30

Oral colon targeted delivery systems for treatment of inflammatory bowel diseases: Synthesis, in vitro and in vivo assessment

Amal H. El-Kamel, Alaa A.-M. Abdel-Aziz, Amal J. Fatani, Hussein I. El-Subbagh

Journal:

International Journal of Pharmaceutics

Année:

2008

Langue:

english

Fichier:

PDF, 956 KB

english, 2008

31

Liquid chromatographic determination of flunarizine dihydrochloride in the presence of its degradation product

Abdel-Aziz M. Wahbi, Abdel-Fattah M. El-Walily, Ekram M. Hassan, Farid G. Saliman, Alaa El-Gendi

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Année:

1995

Langue:

english

Fichier:

PDF, 631 KB

english, 1995

32

Synthesis, dihydrofolate reductase inhibition, antitumor testing, and molecular modeling study of some new 4(3H)-quinazolinone analogs

Sarah T. Al-Rashood, Ihsan A. Aboldahab, Mahmoud N. Nagi, Laila A. Abouzeid, Alaa A.M. Abdel-Aziz, Sami G. Abdel-hamide, Khairia M. Youssef, Abdulrahman M. Al-Obaid, Hussein I. El-Subbagh

Journal:

Bioorganic & Medicinal Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 748 KB

english, 2006

33

Non-classical antifolates. Part 2: Synthesis, biological evaluation, and molecular modeling study of some new 2,6-substituted-quinazolin-4-ones

Fatmah A.M. Al-Omary, Laila A. Abou-zeid, Mahmoud N. Nagi, El-Sayed E. Habib, Alaa A.-M. Abdel-Aziz, Adel S. El-Azab, Sami G. Abdel-Hamide, Mohamed A. Al-Omar, Abdulrahman M. Al-Obaid, Hussein I. El-S

Journal:

Bioorganic & Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 761 KB

english, 2010

34

New ultra-short acting hypnotic: Synthesis, biological evaluation, and metabolic profile of ethyl 8-oxo-5,6,7,8-tetrahydro-thiazolo[3,2-a][1,3]diazepin-3-carboxylate (HIE-124)

Hussein I. El-Subbagh, Hassan A. El-Kashef, Adnan A. Kadi, Alaa A.-M. Abdel-Aziz, Ghada S. Hassan, Justice Tettey, Jochen Lehmann

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 492 KB

english, 2008

35

Synthesis, antimicrobial activity and molecular modeling of cobalt and nickel complexes containing the bulky ligand: bis[N-(2,6-diisopropylphenyl)imino] acenaphthene

Usama El-Ayaan, Alaa A.-M. Abdel-Aziz

Journal:

European Journal of Medicinal Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 417 KB

english, 2005

36

Novel and versatile methodology for synthesis of cyclic imides and evaluation of their cytotoxic, DNA binding, apoptotic inducing activities and molecular modeling study

Alaa A.-M. Abdel-Aziz

Journal:

European Journal of Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 837 KB

english, 2007

37

Solvatochromism, DNA binding, antitumor activity and molecular modeling study of mixed-ligand copper(II) complexes containing the bulky ligand: Bis[N-(p-tolyl)imino]acenaphthene

Usama El-Ayaan, Alaa A.-M. Abdel-Aziz, Shar Al-Shihry

Journal:

European Journal of Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 711 KB

english, 2007

38

Substituted quinazolines, part 3. Synthesis, in vitro antitumor activity and molecular modeling study of certain 2-thieno-4(3H)-quinazolinone analogs

Abdulrahman M. Al-Obaid, Sami G. Abdel-Hamide, Hassan A. El-Kashef, Alaa A.-M. Abdel-Aziz, Adel S. El-Azab, Hamad A. Al-Khamees, Hussein I. El-Subbagh

Journal:

European Journal of Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 742 KB

english, 2009

39

Synthesis of novel pyrazole derivatives and evaluation of their antidepressant and anticonvulsant activities

Mohamed Abdel-Aziz, Gamal El-Din A. Abuo-Rahma, Alaa A. Hassan

Journal:

European Journal of Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 314 KB

english, 2009

40

Synthesis and antitumor evaluation of novel diarylsulfonylurea derivatives: Molecular modeling applications

Magda A. El-Sherbeny, Alaa A.-M. Abdel-Aziz, Musa A. Ahmed

Journal:

European Journal of Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 1.46 MB

english, 2010

41

Synthesis and anti-inflammatory activity of novel (substituted)benzylidene acetone oxime ether derivatives: Molecular modeling study

Mohammed I. El-Gamal, Said M. Bayomi, Saadia M. El-Ashry, Shehta A. Said, Alaa A.-M. Abdel-Aziz, Naglaa I. Abdel-Aziz

Journal:

European Journal of Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 672 KB

english, 2010

42

Synthesis and pharmacological evaluation of novel fused thiophene derivatives as 5-HT2A receptor antagonists: Molecular modeling study

Mohamed M. El-Kerdawy, Eman R. El-Bendary, Alaa A.-M. Abdel-Aziz, Dalia R. El-wasseef, Naglaa I. Abd El-Aziz

Journal:

European Journal of Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 2.88 MB

english, 2010

43

Synthesis and antitumor evaluation of novel cyclic arylsulfonylureas: ADME-T and pharmacophore prediction

Ibrahim M. El-Deeb, Said M. Bayoumi, Magda A. El-Sherbeny, Alaa A.-M. Abdel-Aziz

Journal:

European Journal of Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 1.28 MB

english, 2010

44

Conformational preferences of sterically congested 2-imidazolidinone using X-ray analysis and computational studies. Part 1: Trans-1-acetyl-4,5-di-tert-butyl-2-imidazolidinone

Alaa A.-M. Abdel-Aziz, Mohamed A. Al-Omar, Adel S. El-Azab, Takehisa Kunieda

Journal:

Journal of Molecular Structure

Année:

2010

Langue:

english

Fichier:

PDF, 912 KB

english, 2010

45

Enantioselective synthesis of (1S,2S)-1,2-di-tert-butyl and (1R,2R)-1,2-di-(1-adamantyl)ethylenediamines

Alaa A.-M. Abdel-Aziz, Serry A.A. El Bialy, Fatma E. Goda, Takehisa Kunieda

Journal:

Tetrahedron Letters

Année:

2004

Langue:

english

Fichier:

PDF, 341 KB

english, 2004

46

Corrigendum to “Enantioselective synthesis of (1S,2S)-1,2-di-tert-butyl and (1R,2R)-1,2-di-(1-adamantyl)ethylenediamines” [Tetrahedron Lett. 45 (2004) 8073]

Alaa A.-M. Abdel-Aziz, Serry A.A. El Bialy, Fatma E. Goda, Takehisa Kunieda

Journal:

Tetrahedron Letters

Année:

2004

Langue:

english

Fichier:

PDF, 207 KB

english, 2004

47

Lewis acid-promoted direct substitution of 2-methoxy-3-cyanopyridines by organo cuprates. Part 3: Facile preparation of nicotinamide and nicotinic acid derivatives

Alaa A.-M. Abdel-Aziz

Journal:

Tetrahedron Letters

Année:

2007

Langue:

english

Fichier:

PDF, 320 KB

english, 2007

48

An unusual enhancement of chiral induction by chiral 2-imidazolidinone auxiliaries

Alaa A.-M Abdel-Aziz, Junko Okuno, Shinsuke Tanaka, Tadao Ishizuka, Hirofumi Matsunaga, Takehisa Kunieda

Journal:

Tetrahedron Letters

Année:

2000

Langue:

english

Fichier:

PDF, 69 KB

english, 2000

49

Versatile chiral synthons for 1,2-diamines: (4S,5S)- and (4R,5R)-4,5-dimethoxy-2-imidazolidinones

Ryushi Seo, Tadao Ishizuka, Alaa A.-M Abdel-Aziz, Takehisa Kunieda

Journal:

Tetrahedron Letters

Année:

2001

Langue:

english

Fichier:

PDF, 92 KB

english, 2001

50

Unusual N-acylation of sterically congested trans-4,5-disubstituted 2-imidazolidinones: remarkably facile CC bond formation

Alaa A.-M Abdel-Aziz, Hirofumi Matsunaga, Takehisa Kunieda

Journal:

Tetrahedron Letters

Année:

2001

Langue:

english

Fichier:

PDF, 101 KB

english, 2001